diff --git a/CMakeLists.txt b/CMakeLists.txt
index 6031b7c9..1b2ce554 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -135,7 +135,8 @@ endif()
 
 if (WAMR_BUILD_TARGET MATCHES "X86_.*" OR WAMR_BUILD_TARGET STREQUAL "AMD_64")
   if (NOT (CMAKE_C_COMPILER MATCHES ".*clang.*" OR CMAKE_C_COMPILER_ID MATCHES ".*Clang"))
-    set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
+    # NOTE: The crosscompiler (gcc 5.4 i386) does not support this flag
+    # set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -mindirect-branch-register")
   endif ()
 endif ()