diff --git a/core/iwasm/compilation/aot_llvm.c b/core/iwasm/compilation/aot_llvm.c
index 41d6e5a8..dacdb83d 100644
--- a/core/iwasm/compilation/aot_llvm.c
+++ b/core/iwasm/compilation/aot_llvm.c
@@ -153,6 +153,13 @@ aot_target_precheck_can_use_musttail(const AOTCompContext *comp_ctx)
          */
         return false;
     }
+    if (strstr(comp_ctx->target_arch, "thumb")) {
+        /*
+         * cf.
+         * https://github.com/bytecodealliance/wasm-micro-runtime/issues/2412
+         */
+        return false;
+    }
     /*
      * x86-64/i386: true
      *