diff --git a/core/iwasm/interpreter/wasm_interp_classic.c b/core/iwasm/interpreter/wasm_interp_classic.c
index 67a6237d..8c3f0ae6 100644
--- a/core/iwasm/interpreter/wasm_interp_classic.c
+++ b/core/iwasm/interpreter/wasm_interp_classic.c
@@ -3843,6 +3843,12 @@ wasm_interp_call_func_bytecode(WASMModuleInstance *module,
         HANDLE_OP(WASM_OP_REF_NULL)
         HANDLE_OP(WASM_OP_REF_IS_NULL)
         HANDLE_OP(WASM_OP_REF_FUNC)
+#endif
+#if WASM_ENABLE_JIT != 0 && WASM_ENABLE_SIMD != 0
+        /* SIMD isn't supported by interpreter, but when JIT is
+           enabled, `iwasm --interp <wasm_file>` may be run to
+           trigger the SIMD opcode in interpreter */
+        HANDLE_OP(WASM_OP_SIMD_PREFIX)
 #endif
         HANDLE_OP(WASM_OP_UNUSED_0x14)
         HANDLE_OP(WASM_OP_UNUSED_0x15)
diff --git a/core/iwasm/interpreter/wasm_opcode.h b/core/iwasm/interpreter/wasm_opcode.h
index ce5e358a..276d15c3 100644
--- a/core/iwasm/interpreter/wasm_opcode.h
+++ b/core/iwasm/interpreter/wasm_opcode.h
@@ -683,6 +683,13 @@ typedef enum WASMAtomicEXTOpcode {
 
 #define SET_GOTO_TABLE_ELEM(opcode) [opcode] = HANDLE_OPCODE(opcode)
 
+#if WASM_ENABLE_JIT != 0 && WASM_ENABLE_SIMD != 0
+#define SET_GOTO_TABLE_SIMD_PREFIX_ELEM() \
+    SET_GOTO_TABLE_ELEM(WASM_OP_SIMD_PREFIX),
+#else
+#define SET_GOTO_TABLE_SIMD_PREFIX_ELEM()
+#endif
+
 /*
  * Macro used to generate computed goto tables for the C interpreter.
  */
@@ -906,6 +913,7 @@ typedef enum WASMAtomicEXTOpcode {
         HANDLE_OPCODE(EXT_OP_IF),                    /* 0xd5 */ \
         HANDLE_OPCODE(EXT_OP_BR_TABLE_CACHE),        /* 0xd6 */ \
         SET_GOTO_TABLE_ELEM(WASM_OP_MISC_PREFIX),    /* 0xfc */ \
+        SET_GOTO_TABLE_SIMD_PREFIX_ELEM()            /* 0xfd */ \
         SET_GOTO_TABLE_ELEM(WASM_OP_ATOMIC_PREFIX),  /* 0xfe */ \
         DEF_DEBUG_BREAK_HANDLE()                                \
     };